Numerous Sebaceous Neoplasms in a Patient without Visceral Carcinomas
Identifieur interne : 008242 ( Main/Exploration ); précédent : 008241; suivant : 008243Numerous Sebaceous Neoplasms in a Patient without Visceral Carcinomas
Auteurs : G. Ang [États-Unis] ; C. Campanelli [États-Unis] ; F. Ringpfeil [États-Unis] ; G. Webster [États-Unis] ; J. Lee [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
We present a 58‐year‐old Caucasian man who spawns sebaceous neoplasms with a widely varying histopathologic pattern, the true nature of which were difficult to determine in some of the cases. In a 10‐year period, the patient developed over 20 lesions that varied in size, shape, and location. The patient denied a family history of either similar cutaneous lesions or internal malignancies that would fulfill the criteria of Hereditary Nonpolyposis Colorectal Cancer (HNPCC). Vigilant screening failed to reveal visceral carcinomas. The histopathologic findings of the neoplasms as well as the results of tests for microsatellite instability(MSI) in various tumors and the immunohistochemical staining for the mismatch repair genes (MMR) MSH2 and MLH1 will be discussed. Our patient has been maintained on low‐dose isotretinoin since 1995.
Url:
DOI: 10.1111/j.0303-6987.2005.0320k.x
Affiliations:
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In a 10‐year period, the patient developed over 20 lesions that varied in size, shape, and location. The patient denied a family history of either similar cutaneous lesions or internal malignancies that would fulfill the criteria of Hereditary Nonpolyposis Colorectal Cancer (HNPCC). Vigilant screening failed to reveal visceral carcinomas. The histopathologic findings of the neoplasms as well as the results of tests for microsatellite instability(MSI) in various tumors and the immunohistochemical staining for the mismatch repair genes (MMR) MSH2 and MLH1 will be discussed. Our patient has been maintained on low‐dose isotretinoin since 1995.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Ang, G" sort="Ang, G" uniqKey="Ang G" first="G." last="Ang">G. 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